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Paroxetine: Mode of action
Paroxetine is an antidepressant that selectively reduces the neuronal reuptake of 5-hydroxytryptamine. Affect the pathogenetic link of depression, eliminating the deficit of serotonin. The active substance (paroxetine) has little affinity for muscarinic acetylcholine receptors and the drug has weak anticholinergic effect. People today use Paroxetine to reduce anxiety or insomnia. This medicament rarely causes vomiting or diarrhea.
Paroxetine little effects noradrenaline, dopamine. Paroxetine is not associated with adrenoceptors, thereby it has no hypotensive action or heart affect. It’s said that effect occurs on the second week of the course.
Paroxetine: Indications for use
The main indication – depression of various origins. Paroxetine is used for reactive, atypical, post-psychotic depression, dysthymia. It’s very effective drug for obsessive-compulsive disorder, panic attacks, social phobias, agoraphobia, anxiety disorders of various origins, nightmares.
There are positive results of therapy in Paroxetine patients, whereas the treatment with standard antidepressants proved its unsatisfactory results. Shown the intake of Paroxetine in patients with stress disorder in post-traumatic period. Paroxetine may be used continuously.
Paroxetine: How to use
Paroxetine is taken in the morning, no chewed. Use it after a meal (although the food does not affect absorption of paroxetine), washed down with water. In the treatment of depression, social phobia, post-traumatic disorders, acting under the scheme: Paroxetine 20mg daily for the first few weeks. With the ineffectiveness of the conduct weekly dose increase to 10mg (for example, on the fourth week of the daily dose is paroxetine 40mg, in the third – 30mg). Maximizing the dose of Paroxetine – up to 50mg/day.
For people suffering from panic attacks, prescribed dose is Paroxetine 10mg/day at the beginning of treatment. The minimum dose is used because of the risk of exacerbation of symptoms at the beginning of treatment. The dose may be increased (up to 60mg/day).
Preventive treatment includes paroxetine 20mg dose taken daily. Minimum course of treatment Paroxetine – 4 months. At the end of the course, cancel medication by graduate reduction to paroxetine 10mg/week. Your doctor may prescribe a different scheme discontinuation of the drug if there are unwanted withdrawal symptoms occur.
Paroxetine: Side effects
Nervousness, emotional lability, insomnia
Tremor, myoclonus, seizure manifestations
Worsening depression, depersonalization
Anemic manifestations, lymphadenopathy, leukopenia
Reduction of pressure, orthostatic hypotension
Loss of appetite, violations of the chair
Increase in body weight
Swelling of the face
Before you decide to use Paroxetine, you should get to know about contraindications.
– Patients under 18 years of age;
– In the period of lactation;
– Patients receiving treatment with MAO inhibitors, pimozide, tryptophan, thioridazine;
– With hypersensitivity to paroxetine formulation excipients.
Symptoms of an overdose that can be caused by Paroxetine include: vomiting, nausea, fatigue or excessive excitation, drowsiness, dizziness, cramps, urinary retention, cardiac arrhythmias, syncope, confusion, coma, mydriasis, changes in blood pressure, manic reaction, aggression. May also develop symptoms of liver failure (jaundice, signs of cirrhosis, hepatitis). If co-administration of toxic doses of Paroxetine with psychotropic drugs such ethanol or other typical – fatality is possible.
Storage temperature of Paroxetine – no higher than 30 degrees Celsius. The storage area should be dry and away from children, protected from light. Shelf life of Paroxetine – 36 months.
Before you use paroxetine, you should consult your doctor. All the information above is intended for review. It’s not recommended to use Paroxetine with no rx.